Articles

Articles

The Olivamine 10® Science

The Olivamine 10® Science

Olivamine 10® is based upon the use of small molecules, delivered transcutaneously to the skin or "trophically." Trophic is from the Greek (trophikos) pertaining to nutritive processes. Corneotrophism pertains to the delivery of nutrients through the skin's epidermis for the purpose of treating skin and providing amino acids, vitamins, and antioxidants necessary for cellular homeostasis. Download Complete Article

Antipruritic Activity of Nutrashield and Skin Repair - April 11, 2006

Antipruritic Activity of Nutrashield and Skin Repair - April 11, 2006

Pruritus, or itch, is a symptom associated with numerous skin diseases and skinlesions. The pruritic response in skin can be extremely intense, causing severe pain discomfort for long periods of time1. The prominent biochemical trigger responsible for pruritus is the degranulation of dermal mast cells and the subsequent release of histamine. Histamine, or imidazolethylamine, is a biogenic amine present in numerous metachromatic granules in mast cells. When released, histamine acts on endothelial H1 nerve receptors and elevates the concentration of cyclic adenosine monophosphate in the primary neurons. An expansion of the capillaries occurs, along with local edema and an increase in the volume of the vascular bed. The cyclic adenosine monophosphate signaling pathway excites pruritic nerve C-fibers near the dermal epidermal junction, thus inducing pruritus. Circulating histamine is eventually inactivated by the liver viaseveral methylation and oxidation reactions. Download Complete Article

Comparative Study of Medline Nutrashield - May 20, 2005

Comparative Study of Medline Nutrashield - May 20, 2005

A study was conducted to assess and compare wash-off resistance and Moisture Vapor Transmission Rate (MVTR) of Medline Nutrashield to several other commercially available products. Results from these studies demonstrate the ability of Nutrashield to resist wash-off longer and through more wash-offs than the comparative products. The following report documents the results and test methods used.Download Complete Article

Corneotherapy - May 5, 2005

Corneotherapy - May 5, 2005

Preventive corneotherapy, a term coined in the 1990s by Albert Kligman, M.D., Ph.D., is becoming one of the most important principles of treatment in advanced skin care. The object of corneotherapy, topical delivery of active concentrates through the skin, is skin barrier homeostasis.1 The ultimate development in the quest for understanding the stratum corneum is corneotherapy, focusing therapy toward correcting the defective horny layers. Download Complete Article

Dawn of Advanced Skin Care - September 2004

Dawn of Advanced Skin Care - September 2004

Skin care is a four-pronged approach with cleansing, moisturizing, protecting, and now nourishing being the key steps. The largest organ of the body, the integument, receives one third of the human body’s cardiac output, feeding and nourishing it from the inside. This article will delve into the concept of additionally feeding the skin from the outside, the dawn of advanced skin care. See Table 1 for the hierarchy or generations of available skin care products. Download Complete Article

Hyperbaric Study - March 9, 2007

Hyperbaric Study - March 9, 2007

Current protocol call for a cessation of adjunctive skin care treatments during hyperbaric care. The elevation of the oxygen fraction along with the increased pressure in the hyperbaric chamber dramatically increases the flammability potential of the materials in the hyperbaric atmosphere, leading to the need for rigorous standards to prevent the possibility of flame ignitions. A scientific method of evaluating the flammability risks associated with the use of skin care products in the hyperbaric setting would be a clinically helpful tool. Download Complete Article

Neonatal Emollient Flammability - March 27, 2006

Neonatal Emollient Flammability - March 27, 2006

Neonatal skin maturation requires the proper development of the dermis, epidermis and the outermost, semipermeable barrier provided by the stratum corneum. The stratum corneum becomes fully keratinized in utero between 32 and 34 weeks gestational age. Premature neonates are frequently delivered with severely underdeveloped stratum corneum and epidermal skin layers. The delay in tissue maturation disallows the numerous protective functions provided by fully developed skin. Download Complete Article

Neonatal Study - October 25, 2006

Neonatal Study - October 25, 2006

Neonatal health care has continued to advance over a period spanning three decades. However, the treatment of preterm and term infant skin has lagged behind. Current AWHONN and NANN guidelines call for the use of a petrolatum-based product in the neonate setting. Petrolatum may pose significant risks associated with NICU fire hazards, barrier occlusion, microbial contamination and toxin absorption. In order to reduce infant mortality and improve neonatal skin care, advanced emollient technologies should be considered. Semipermeable silicone derivatives have demonstrated a reduced rate of combustion as compared to petrolatum. Silicone derivatives also sustain transcutaneous respiration while preventing e-TEWL. Certain silicone-based emollients have further demonstrated a reduced rate of microbial contamination and toxin absorption. The purpose of this report is to review the risks associated with current highly-flammable and occlusive infant skin care products and discuss the benefits of oxygen-compatible, silicone-based neonatal emollients. Download Complete Article

Neonatal Skin Care Product Selection in High Oxygen Environment - February 22, 2006

Neonatal Skin Care Product Selection in High Oxygen Environment - February 22, 2006

Skin care product selection may be essential to improving safety in oxygen-enriched, neonatal environments. Independent studies were conducted comparing the oxygen compatibility of the industry standard, a petrolatum-based product, against newer silicone-based products. Oxygen compatibility was determined via autogenous ignition temperature testing, oxygen index testing and heat of combustion testing. Autogenous ignition temperature is a relative indication of a material’s propensity for ignition, oxygen index is a relative indication of a material’s flammability, and heat of combustion is the absolute value of a material’s energy release. Skin care products with a high autogenous ignition temperature, a high oxygen index and a low heat of combustion are recognized as being more compatible for application in oxygen-enriched environments. Download Complete Article

Radiation Study Brochure - June 7, 2006

Radiation Study Brochure - June 7, 2006

The objective of the study was to determine if new micronutrient skin care technologies could outperform the Standard-of-Care (SOC) by reducing the incidence of radiodermatitis while improving the patient’s perceived Quality-of-Life (QL) during radiotherapy. Breast cancer patients have bene_ted from skin sparing technologies, but remain at high risk of skin breakdown associated with radiation dermatitis. Ninety two to ninety six percent of breast cancer patients will experience skin reaction and lost QL. The study utilized validated scoring documents developed by the Oncology Nursing Society and Dermatology Life Quality Index (DLQI). Eighty two patients receiving radiotherapy were evaluated in the year-over-year study. Forty one patients received the SOC, Natural Care® Gel (NCG) from Bard Medical and Aquaphor® Healing Ointment (AQ) from Beiersdorf AG. Download Complete Article

The Role of Free Radicals and Related Cell Repair - September 15, 2004

The Role of Free Radicals and Related Cell Repair - September 15, 2004

DNA damage to the skin’s cells accumulates with cancer treatment making skin cells vulnerable to free radical damage. In one study, it was found that cellular DNA damage was between 2-4% in young adult cells. The damage was 6 times that amount in the elderly. Elderly skin cells have less capacity to repair themselves than those of young adults and this may explain some of the decline in the skin’s immune function associated with aging. The treatments associated with cancer, chemotherapy and radiation will damage skin cells and without regard to age, everything that can be done to help these cells heal with be beneficial in the short and long run. Download Complete Article

The skin and its healing processes are altered in patients with diabetes - October 30, 2006

The skin and its healing processes are altered in patients with diabetes - October 30, 2006

Purpose: Elucidate early and late stage diabetic skin pathophysiologies that lead to skin breakdown, wounding and potential loss of limb. Glycation, oxidation, inflammation, loss of microcirculation commence the cascade that leads to ischemia, neuropathy, collagen cross-linking and pruritus. The etiologies of this disease on the skin’s immune system may best be directed to the field of biochemistry where micronutrients that have demonstrated efficacy against these disorders are now being incorporated into topical corneotherapeutic products. Download Complete Article

Topical Micronutrient Products Reduced Radiation Dermatitis - June 7, 2006

Topical Micronutrient Products Reduced Radiation Dermatitis - June 7, 2006

Objective: To determine if new micronutrient skin care technologies could outperform the Standard-of-Care (SOC) by reducing the incidence of radiodermatitis while improving the patient’s perceived Quality-of-Life during radiotherapy. Breast cancer patients have benefited from skin sparing technologies, but remain at high risk of skin breakdown associated with radiation dermatitis. Ninety two to ninety six percent of breast cancer patients will experience skin reaction and lost Quality-of-Life Download Complete Article

Using Olivamine 10® Contain Products for Pruritic and Lymphedema Symptoms - August 20, 2007

Using Olivamine 10® Contain Products for Pruritic and Lymphedema Symptoms - August 20, 2007

Localized lymphedema in obese patients results in numerous symptoms associated with skin breakdown. One of the symptoms that most affects the patient being treated is pruritus, or itch. The pruritic response in skin can be extremely intense, causing severe pain and discomfort for long periods of time. The prominent biochemical trigger responsible for pruritus is the degranulation of DMCs and the subsequent release of HA. In addition, secondary biochemical factors present in infected and inflamed skin lower the threshold for DMC degranulation and potentiate the itch provoked by HA. Nine morbidly obese patients with mild to severe pruritus associated with localized lymphedema were evaluated over a six month period. All patients followed a treatment regimen that utilized several advanced skin care products. At the end of the study, 95% of the patients’ pruritic symptoms were completely resolved. In fact, 7 out of 9 patients reported that their pruritic symptoms had disappeared in a matter of days. The treatment regimen provided numerous beneficial nutrients that reduced overall HA activity and inhibited the secondary biochemical mediators associated with pruritus. Additional research should be completed in order to further improve patient quality of life by diminishing the agony and discomfort that accompanies lymphedema-induced pruritus. Download Complete Article

Skin Disease and Treatment With Olivamine 10® - May 16, 2008

Skin Disease and Treatment With Olivamine 10® - May 16, 2008

Olivamine 10®-based skin care products contain several specialized nutrients that effectively modulate the biochemical abnormalities associated with pruritus/pain. The anti-pruritic nutrients include hydroxytyrosol (HT), or 3,4-dihydroxyphenyl ethanol, which is a simple phenol found predominantly in Olea europea, or the olive plant. HT is an extremely potent free radical scavenger that stimulates significant anti-inflammatory activity in skin (Bitler et al.). Numerous studies have established that topically applied antioxidants substantially reduce pruritus by inhibiting the secondary biochemical factors present in infected and inflamed skin (Hadshiew et al.). Download Complete Article

Improving Skin Tear Outcomes using Olivamine 10® a Topical Nourishing Skin Care Cream - May 10, 2006

Improving Skin Tear Outcomes using Olivamine 10® a Topical Nourishing Skin Care Cream - May 10, 2006

Methodology: Pre and post-study, at- risk patients were identified for the risk of skin trauma (skin tears, abrasions and bruising) using a Skin Trauma Risk Assessment Sheet adapted by our wound and skin team. The tool is done on admission, weekly x 4 then quarterly and includes risk factors such as medications, presence of purpura, turgor and level of assist required. Scores between 1 and 6 indicate moderate risk. Scores between 6 and 12 indicate high risk. Download Complete Article

Help your skin with Remedy - April 2005

Help your skin with Remedy - April 2005

A Study of "Decreasing the Incidence of Skin Tears in the Extended Care Setting with the Use of a New Line of Advanced Skin Care Products containing Olivamine 10®, including Remedy Skin Care Products" - Marjorie Groom, RN,BSN, MSHCA, CWOCN, DAPWCA, Memorial Hospital, Belleville, IL. Read Complete Article Download Complete Article